Process for producing n-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine and intermediate

ABSTRACT

The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2):  
                 
 
wherein R is C 1-4  alkyl, comprising the step of reducing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):  
                 
wherein R is as defined above. According to the present invention, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.

TECHNICAL FIELD

The present invention relates to a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine. N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamines are highly reactive and useful as intermediates for various pharmaceuticals. The present invention relates also to a novel compound for use as a production intermediate of an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine, i.e., a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, and a production process thereof.

BACKGROUND ART

An example of a method known for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine is reducing 1-(2-thienyl)-3-chloropropane-1-one with sodium borohydride in ethanol to give 3-chloro-1-(2-thienyl)-1-propanol, halogen-exchanging this 3-chloro-1-(2-thienyl)-1-propanol with sodium iodide in acetone to give 3-iodo-1-(2-thienyl)-1-propanol, and reacting this 3-iodo-1-(2-thienyl)-1-propanol with an aqueous monomethylamine solution in tetrahydrofuran (CHIRALITY, 12, 26-29 (2000)). This method is not industrially advantageous since the starting material, i.e., 1-(2-thienyl)-3-chloropropane-1-one, is a highly unstable compound.

An example of a method known for producing N,N-dimethyl-3-hydroxy-3-(2-thienyl)propanamine is reacting 2-acetylthiophene with a dimethylamine hydrochloride in isopropanol in the presence of paraformaldehyde and hydrochloric acid to give 2-thienyl 2-dimethylaminoethyl ketone, and reducing this ketone with sodium borohydride in ethanol (Japanese Unexamined Patent Publication No. 1995-188065).

When an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine is produced according to the method described immediately above using a monoalkylamine hydrochloride in place of a dimethylamine hydrochloride, it is problematic in that a dimeric N,N′,N″-alkyl-bis[1-[3-oxo-3-(2-thienyl)propane]]amine is generated due to the unstable production intermediate, i.e., 2-thienyl 2-monoalkylaminoethyl ketone, which results in a low yield of N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine obtained after the reduction with sodium borohydride.

DISCLOSURE OF THE INVENTION

An object of the present invention is to provide a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine in an industrially inexpensive and easy manner, and a production intermediate thereof.

Other objects and characteristics of the present invention will become evident by the disclosure provided hereinbelow.

The inventors conducted extensive research to attain the objectives described above and found that a novel compound, i.e., a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, is useful as a starting material for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine. They found also that, by reducing this novel compound, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine can be produced in an industrially inexpensive and easy manner and that this (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine can be produced by reacting an alkali metal salt of β-oxo-β-(2-thienyl)propanal with a monoalkylamine compound. The inventors accomplished the present invention based on these findings.

In other words, the present invention provides processes for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine, a production intermediate of this compound, i.e., a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, and production processes thereof as described below:

-   1. A process for producing an     N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by     General Formula (2):     wherein R is C₁₋₄ alkyl, comprising the step of reducing a     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by     General Formula (1):     wherein R is as defined above. -   2. The process according to Item 1, wherein the     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced using     sodium borohydride or sodium cyanoborohydride. -   3. The process according to Item 1 or 2, wherein the     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced in the     presence of a proton-donating compound. -   4. A (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by     General Formula (1):     wherein R is C₁₋₄ alkyl. -   5. The (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine according to     Item 4, wherein R in General Formula (1) is methyl. -   6. A process for producing a     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by     General Formula (1):     wherein R is C₁₋₄ alkyl, comprising the step of reacting an alkali     metal salt of β-oxo-β-(2-thienyl)propanal represented by General     Formula (3):     wherein M is an alkali metal atom, with a monoalkylamine compound     represented by General Formula (4):     H₂N—R  (4)     wherein R is as defined above. -   7. A process for producing an     N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by     General Formula (2):     wherein R is C₁₋₄ alkyl, comprising the steps of:     -   reacting an alkali metal salt of β-oxo-β-(2-thienyl)propanal         represented by General Formula (3):         wherein M is an alkali metal atom, with a monoalkylamine         compound represented by General Formula (4):         H₂N—R  (4)         wherein R is as defined above, to give a         (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by         General Formula (1):         wherein R is as defined above; and     -   reducing the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine. -   8. The process according to Item 7, wherein the     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced using     sodium borohydride or sodium cyanoborohydride. -   9. The process according to Item 7 or 8, wherein the     (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced in the     presence of a proton-donating compound.

Hereinbelow, the process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine, the production intermediate of this compound, i.e., a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, and the production process thereof are described in more detail.

[Production of N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine]

The method for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine comprises the step of reducing a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is C₁₋₄ alkyl.

Examples of C₁₋₄ alkyl are methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, etc.

Examples of reducing agents usable for the reduction are diisobutylaluminum hydride and like metal hydrides; sodium borohydride, sodium cyanoborohydride, lithium borohydride, potassium borohydride, and like complex metal hydrides; borane, 9-borabicyclo[3,3,1]nonane, and like borane compounds; hydrogen; etc. Among such reducing agents, complex metal hydrides are preferable because of their high reducing power, with sodium borohydride and sodium cyanoborohydride being particularly preferable.

The amount of reducing agent is preferably 0.1 to 7 mol, and more preferably 0.2 to 5 mol, per mol of (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine. Amounts of reducing agent less than 0.1 molar equivalents are likely to result in an impaired yield because the reaction does not proceed sufficiently. On the other hand, amounts of reducing agent exceeding 7 mol do not exert effects justifiable for such amounts, and are therefore not economical.

Examples of reaction solvents usable in the reduction of the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine are pentane, hexane, cyclohexane, heptane, and like aliphatic hydrocarbons; benzene, toluene, xylene, chlorobenzene, and like aromatic hydrocarbons; diethyl ether, tetrahydrofuran, dioxane, and like ethers; methanol, ethanol, and like alcohols; methyl acetate, ethyl acetate, butyl acetate, and like esters; etc. Among such reaction solvents, aromatic hydrocarbons are preferable, and toluene is particularly preferable.

The amount of reaction solvent is preferably 0.1 to 30 times, and more preferably 0.5 to 20 times, the weight of (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine. Amounts of reaction solvent less than 0.1 times are likely to make stirring difficult. On the other hand, amounts of reaction solvent exceeding 30 times are likely to impair volume efficiency.

The reduction of the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is preferably carried out in the presence of a proton-donating compound for the reduction reaction to proceed efficiently. Examples of proton-donating compounds are methanol, ethanol, and like alcohols; formic acid, acetic acid, monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, and like carboxylic acids; hydrogen fluoride, hydrogen chloride, hydrogen bromide, hydrogen iodide, and like hydrogen halides; sulfuric acid; methylsulfuric acid, p-toluenesulfonic acid, and like sulfonic acids; etc. Among such examples, carboxylic acids are preferable, and acetic acid is particularly preferable, for the reduction reaction to readily progress.

The amount of proton-donating compound is preferably 20 mol or less, and more preferably 0.1 to 10 mol, per mol of (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine. Amounts of proton-donating compound exceeding 20 molar equivalents do not exert effects justifiable for such amounts, and are therefore not economical.

The temperature for reducing the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is preferably from 0° C. to 150° C., and more preferably from 20° C. to 100° C. Temperatures lower than 0° C. are likely to slow the reaction rate, thereby prolonging the reaction. On the other hand, temperatures exceeding 150° C. may result in impurity generation. Although the reaction time varies depending on the reaction temperature, it is preferably from 1 to 30 hours.

After the reaction, the reaction solution containing the N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine is phase-separated by adding water when a water-immiscible solvent is used as a reaction solvent. When a water-miscible solvent is used as a reaction solvent, water and a water-immiscible solvent, e.g., toluene, are added for phase separation. The solvent contained in the organic phase obtained by the phase separation is distilled off, and crystals thus precipitated are then recrystallized, thereby enabling the N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine to be isolated.

The N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine thus obtained is a compound represented by General Formula (2):

wherein R is C₁₋₄ alkyl.

Examples of C₁₋₄ alkyl are methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, etc.

Specific examples of N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamines are N-monomethyl-3-hydroxy-3-(2-thienyl)propanamine, N-monoethyl-3-hydroxy-3-(2-thienyl)propanamine, N-mono(n-propyl)-3-hydroxy-3-(2-thienyl)propanamine, N-monoisopropyl-3-hydroxy-3-(2-thienyl)propanamine, N-mono(n-butyl)-3-hydroxy-3-(2-thienyl)propanamine, N-mono(t-butyl)-3-hydroxy-3-(2-thienyl)propanamine, etc.

Such N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamines are highly reactive and useful as intermediates for various pharmaceuticals.

The (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is C₁₋₄ alkyl, used in the process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine of the invention is a novel compound.

Examples of C₁₋₄ alkyl are methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, etc.

Specific examples of (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamines are (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine, (Z)-N-monoethyl-3-oxo-3-(2-thienyl)propenamine, (Z)-N-mono(n-propyl)-3-oxo-3-(2-thienyl)propenamine, (Z)-N-monoisopropyl-3-oxo-3-(2-thienyl)propenamine, (Z)-N-mono(n-butyl)-3-oxo-3-(2-thienyl)propenamine, (Z)-N-mono(t-butyl)-3-oxo-3-(2-thienyl)propenamine, etc. Among such examples, (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine is preferable.

Production of (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine

(Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamines represented by General Formula (1) can be obtained by reacting an alkali metal salt of β-oxo-β-(2-thienyl)propanal represented by General Formula (3):

wherein M is an alkali metal atom, with a monoalkylamine compound represented by General Formula (4): H₂N—R  (4) wherein R is C₁₋₄ alkyl.

Alkali metal salts of β-oxo-β-(2-thienyl)propanal usable in the present invention are compounds represented by General Formula (3):

wherein M is an alkali metal atom.

Examples of alkali metal atoms are lithium, sodium, potassium, etc.

Specific examples of alkali metal salts of β-oxo-β-(2-thienyl)propanal are the lithium salt of β-oxo-β-(2-thienyl)propanal, the sodium salt of β-oxo-β-(2-thienyl)propanal, the potassium salt of β-oxo-β-(2-thienyl)propanal, etc. Among such examples, the sodium salt of β-oxo-β-(2-thienyl)propanal is preferable.

Methods for producing alkali metal salts of β-oxo-β-(2-thienyl)propanal usable in the present invention are not limited. An example thereof is to react 2-acetylthiophene with an alkali metal methoxide in ethyl formate (Japanese Unexamined Patent Publication No. 1990-202865).

Monoalkylamine compounds usable herein are compounds represented by General Formula (4): H₂N—R  (4) wherein R is C₁₋₄ alkyl.

Examples of C₁₋₄ alkyl are methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, etc.

Specific examples of monoalkylamine compounds are monomethylamine, monoethylamine, mono(n-propyl)amine, monoisopropylamine, mono(n-butyl)amine, mono(t-butyl)amine, etc. Among such examples, monomethylamine is preferable.

Hydrochloric acid salts and sulfuric acid salts of the aforementioned monoalkylamine compounds can be used as monoalkylamine compounds in the present invention.

The amount of monoalkylamine compound is preferably 1 to 5 mol, and more preferably 1 to 3 mol, per mol of alkali metal salt of β-oxo-β-(2-thienyl)propanal. Amounts of monoalkylamine compound less than 1 mol are likely to result in an impaired yield. On the other hand, amounts of monoalkylamine compound exceeding 5 mol do not exert effects justifiable for such amounts, and are therefore not economical.

Examples of reaction solvents usable in the reaction of the alkali metal salt of β-oxo-β-(2-thienyl)propanal and the monoalkylamine compound are pentane, hexane, cyclohexane, heptane, and like aliphatic hydrocarbons; benzene, toluene, xylene, chlorobenzene, and like aromatic hydrocarbons; diethyl ether, tetrahydrofuran, dioxane, and like ethers; methanol, ethanol, and like alcohols; methyl acetate, ethyl acetate, butyl acetate, and like esters; etc. Among such reaction solvents, alcohols are preferable, and methanol is particularly preferable.

The amount of reaction solvent is preferably 0.1 to 30 times, and more preferably 0.5 to 20 times, the weight of alkali metal salt of β-oxo-β-(2-thienyl)propanal. Amounts of reaction solvent less than 0.1 times are likely to make stirring difficult whereas amounts of reaction solvent exceeding 30 times are likely to impair volume efficiency.

The temperature for the reaction of the alkali metal salt of β-oxo-β-(2-thienyl)propanal with the monoalkylamine compound is preferably from 0° C. to 100° C., and more preferably from 10° C. to 80° C. Reaction temperatures lower than 0° C. are likely to slow the reaction rate, thereby prolonging the reaction. On the other hand, reaction temperatures exceeding 100° C. are likely to result in impurity generation. Although the reaction time varies depending on the reaction temperature, it is preferably from 1 to 30 hours.

After the reaction, the solvent is distilled off, and an aqueous sodium hydroxide solution and an organic solvent such as methyl t-butyl ether, toluene, or the like are added to the reaction solution for phase separation to obtain an organic phase. The solvent is distilled off from the thus-obtained organic phase, and the thus-precipitated crystals are washed and dried, thereby enabling the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to be isolated.

Moreover, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine can be obtained without isolating the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine above by subjecting it to reduction.

The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine in an industrially inexpensive and easy manner, which is highly reactive and useful as an intermediate for various pharmaceuticals, and a production intermediate thereof.

BEST MODE FOR CARRYING OUT THE INVENTION

Examples are given below to illustrate the invention in more detail, but the scope of the invention is not limited to these examples.

EXAMPLE 1

88.1 g (0.50 mol) of the sodium salt of β-oxo-β-(2-thienyl)propanal and 168 g of methanol were introduced into a 1-liter 4-necked flask equipped with a stirrer, condenser, thermometer and dropping funnel. 87.8 g (0.50 mol) of a 38.5 wt. % aqueous monomethylamine hydrochloride solution was added dropwise at 25° C. over 20 minutes. After the dropwise addition, reaction was carried out at 30° C. for 5 hours.

After the reaction, methanol was distilled off, and 121.4 g of a 3.1 wt. % aqueous sodium hydroxide solution and 100 g of methyl t-butyl ether were added for phase separation. The solvent was distilled off from the organic phase thus separated, and the thus-precipitated crystals were filtered. The crystals thus obtained were washed twice with 100 g of ethanol and dried, thereby giving 62.5 g (0.374 mol) of (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine. The yield thereof based on the sodium salt of β-oxo-β-(2-thienyl)propanal was 74.8%.

The (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine thus obtained exhibited the following properties:

Molecular weight: 167.23

Melting point: 85.3° C. to 86.4° C.

Elemental analysis: C, 57.23%; H, 5.55%; N, 8.38%

(theoretical value: C, 57.46%; H, 5.42%; N, 8.37%)

Infrared absorption spectrum (KBr, cm⁻¹): 3230, 3079, 3064, 2929, 2904, 2813, 1629, 1552, 1513, 1488, 1427, 1413, 1351, 1290, 1251, 1234, 1176, 1145, 1093, 1060, 1012, 979, 954, 856, 842, 759, 740, 698, 663, 565, 468, 453

¹H-NMR spectrum (CDCl₃, TMS standard) δ (ppm): 9.90 (b, 1H), 7.54 (dd, 1H), 7.45 (dd, 1H), 7.06 (dd, 1H), 6.85 (dd, 1H), 5.57 (d, 1H), 3.05 (d, 3H)

EXAMPLE 2

8.7 g (0.052 mol) of (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine as obtained in Example 1, 6.2 g (0.103 mol) of acetic acid, and 42 g of toluene were introduced into a 300 ml 4-necked flask equipped with a stirrer, condenser, thermometer and dropping funnel, and heated to 50° C. After adding 1.966 g (0.052 mol) of sodium borohydride, reaction was carried out at 80° C. for 2 hours.

After the reaction, the reaction solution was cooled to 25° C., and 30 g of a 12.5 wt. % aqueous sodium hydroxide solution was added thereto for phase separation. The solvent was distilled off from the organic phase thus separated, and the thus-precipitated crystals were filtered. The crystals thus obtained were recrystallized in a mixed solvent of toluene and heptane (weight ratio=1:3), thereby giving 6.5 g (0.039 mol) of N-monomethyl-3-hydroxy-3-(2-thienyl)propanamine. The yield thereof based on (Z)-N-monomethyl-3-oxo-3-(2-thienyl)propenamine was 75.0%.

EXAMPLE 3

88.1 g (0.50 mol) of the sodium salt of β-oxo-β-(2-thienyl)propanal and 168 g of methanol were introduced into a 1-liter 4-necked flask equipped with a stirrer, condenser, thermometer and dropping funnel. 87.8 g (0.50 mol) of a 38.5 wt. % aqueous monomethylamine hydrochloride solution was added dropwise at 25° C. over 20 minutes. After the dropwise addition, reaction was carried out at 30° C. for 5 hours.

After the reaction, methanol was distilled off, and 400 g of toluene was added for phase separation. The organic phase obtained by phase separation was returned to the flask, and water was distilled off at 110° C. Toluene that had been distilled off during distillation due to azeotropy with water was separated from the water and returned to the flask. The organic phase was cooled to 25° C., mixed with 60 g (1.0 mol) of acetic acid, and heated to 50° C. After adding 18.9 g (0.5 mol) of sodium borohydride, reaction was carried out at 80° C. for 2 hours.

After the reaction, the reaction solution was cooled to 25° C., and 290 g of a 12.5 wt. % aqueous sodium hydroxide solution was added thereto for phase separation. The solvent was distilled off from the organic phase thus separated, and the thus-precipitated crystals were filtered. The crystals thus obtained were recrystallized in a mixed solvent of toluene and heptane (weight ratio=1:3), thereby giving 61.6 g (0.36 mol) of N-monomethyl-3-hydroxy-3-(2-thienyl)propanamine. The yield thereof based on the sodium salt of β-oxo-β-(2-thienyl)propanal was 72.0%. 

1. A process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2):

wherein R is C₁₋₄ alkyl, comprising the step of reducing a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is as defined above.
 2. The process according to claim 1, wherein the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced using sodium borohydride or sodium cyanoborohydride.
 3. The process according to claim 1, wherein the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced in the presence of a proton-donating compound.
 4. A (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is C₁₋₄ alkyl.
 5. The (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine according to claim 4, wherein R in General Formula (1) is methyl.
 6. A process for producing a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is C₁₋₄ alkyl, comprising the step of reacting an alkali metal salt of β-oxo-β-(2-thienyl)propanal represented by General Formula (3):

wherein M is an alkali metal atom, with a monoalkylamine compound represented by General Formula (4): H₂N—R  (4) wherein R is as defined above.
 7. A process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2):

wherein R is C₁₋₄ alkyl, comprising the steps of: reacting an alkali metal salt of β-oxo-β-(2-thienyl)propanal represented by General Formula (3):

wherein M is an alkali metal atom, with a monoalkylamine compound represented by General Formula (4): H₂N—R  (4) wherein R is as defined above, to give a (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1):

wherein R is as defined above; and reducing the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine.
 8. The process according to claim 7, wherein the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced using sodium borohydride or sodium cyanoborohydride.
 9. The process according to claim 7, wherein the (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is reduced in the presence of a proton-donating compound. 